This prospective cohort study was designed to address whether 1 mg of oral vitamin K effectively reduces the INR value of such patients. The most appropriate management strategy in these patients is unknown. Ffp may be administered instead of PCC or rFVIIa if those therapies are unavailable. For soft tissue bleeding, 100 units/kg every 12 hours is recommended.įor severe hemorrhage (eg, central nervous system bleeding), 100 units/kg every 12 hours is recommended, although a more frequent dosing interval (ie, 6 h) may be indicated until clear clinical improvement is achieved. The lower range is recommended for joint or mucous membrane bleeding. Mplex concentrate (PCC), as a general guideline, a dosage of 50-100 units/kg IV at 12-hour intervals is recommended. In this article we will be discussing a very common question: vitamin k antidote.
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